Turbo-charging pharmaceutical biotechnology simulations

New simulation technology developed by TU Graz is designed to make the production of biopharmaceuticals more efficient, cost-effective and comprehensible for manufacturers.

A man with computer in front of an oversized plexiglass tube with water

Christian Witz from the Institute for Process and Particle Technology at TU Graz in front of a Plexiglas model of a stirred and gassed (bio)reactor © TU Graz

Demand for biopharmaceuticals is strong: biopharmaceutical active ingredients – in other words, genetically engineered drugs – accounted for seven of the ten top-selling medications in the world in 2018. And the proportion is set to rise, as biopharmaceuticals can be used to combat conditions such as multiple sclerosis and anaemia, as well as many forms of cancer and rare diseases, which cannot be treated with chemical and synthetic agents. But such efficacy comes at a price. While chemically produced medicines are “small molecules” that are relatively easy to manufacture and are available in tablet form, biopharmaceutical drugs usually comprise hundreds or thousands of atoms.

Switch to the News+Stories article about the ComBioPro project to learn more about how computer-based simulations enhance process knowledge which could significantly speed up the scale-up from the lab to production scale.